Arsenal manager Mikel Arteta is without a number of players
Arsenal are missing Thomas Partey, Mohamed Elneny, Pierre-Emerick Aubameyang and Nicolas Pepe, with the quartet all called up by their countries for the Africa Cup of Nations.
They were also without Martin Odegaard for the Carabao Cup game at Liverpool on Thursday night, after the Norewgian returned a positive Covid test, while Xhaka's first-half red card is due to rule him out of Sunday's game if it goes ahead as planned.
Bukayo Saka was taken off in the closing stages of the game at Anfield, with Arteta casting doubt on whether the England international would be involved on Sunday.
"He felt something in the last minutes, he was really fatigued," Arteta said after Saka failed to complete the game against Liverpool, with Nuno Tavares taking his place for the final few minutes.
"I don’t know [if he will be ready for Sunday]. He’s a young boy and he recovers really quickly.
"But he’s played a lot of minutes in the last few months so let’s see who is available."
Saka was forced off early against Liverpool
Arsenal sit fifth in the Premier League table ahead of the weekend's fixtures, two points ahead of Spurs, though Antonio Conte's side have two games in hand on their neighbours.
The reverse fixture saw the Gunners pick up a 3-1 win back in September, with all of their goals arriving in the first half.
Emile Smith Rowe, who scored the opener in that game, missed Arsenal's midweek match as he moves closer to a comeback, while Calum Chambers and Takehiro Tomiyasu are also injury concerns.
Spurs, meanwhile, have a number of absentees of their own, with Conte confirming England international Eric Dier would not be back from injury in time for Sunday.
Son Heung-min is also out of action, and is unlikely to return to the pitch before next month, while centre-back Cristian Romero has yet to make his return from an injury suffered back in November.