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As a new era begins at Manchester United following the departure of Ole Gunnar Solskjaer, United will be looking to start things off right with a win in Europe.
A 4-1 thumping at Watford was ultimately the final nail in the coffin for Solskjaer with Michael Carrick now in charge of first team affairs for the time being.
Carrick will be the main man in the dugout for the first time tonight as the Red Devils take on Villarreal, in an attempt to progress in the Champions League.
United still remain in pole position to win Group F despite their league struggles and three points at the Estadio de la Ceramica would go a long way to securing a spot in the knock-out stage of the marquee European competition this campaign.
Here's all you need to know about the match:
Where and when is it?
The match takes place at the Estadio de la Ceramica on Tuesday, November 22.
What time is kick-off?
The action gets underway at 5.45pm.
What channel is it on?
TV channel: The match will be televised on BT Sport 3 with coverage starting at 5pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or through the BT Sport app.
Irish fans will also be able to watch the match on a fully free-to-air platform, via the LiveScore app. Users will also be able to watch the matches on their mobile or tablet devices, with the further option to ‘cast’ the action to their TV screens.
Luke Shaw will not be available for United as he misses the match due to concussion protocol after taking a blow to the head.
Mason Greenwood will also miss the trip to Spain as he tested positive for coronavirus last week.
Raphael Varane is out with a hamstring problem and Paul Pogba is still struggling with with a thigh strain.
Donny van de Beek could remarkably ignite his Man United career under Carrick and he is expected to start the match.
Predicted 4-2-3-1 line-up: De Gea; Wan-Bissaka, Lindelof, Maguire, Telles; McTominay, Van de Beek; Sancho, Fernandes, Rashford; Ronaldo
Villarreal win: 79/40
Manchester United win: 32/21
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